Gene- and cell-based therapies offer a potential paradigm shift away from traditional devices and drugs toward biologics for the treatment of cardiac rhythm disorders.
Do gene- and cell-based therapies provide effective alternatives to devices and drugs for treating cardiac rhythm disorders?
Biological therapies such as gene and cell-based approaches offer a potential future paradigm shift for treating cardiac arrhythmias.
Cardiac rhythm disorders reflect failures of impulse generation and/or conduction. With the exception of ablation methods that yield selective endocardial destruction, present therapies are nonspecific and/or palliative. Progress in understanding the underlying biology opens up prospects for new alternatives. This article reviews the present state of the art in gene- and cell-based therapies to correct cardiac rhythm disturbances. We begin with the rationale for such approaches, briefly discuss efforts to address aspects of tachyarrhythmia, and review advances in creating a biological pacemaker to cure bradyarrhythmia. Insights gained bring the field closer to a paradigm shift away from devices and drugs, and toward biologics, in the treatment of rhythm disorders.
Cho et al. (Thu,) conducted a review in Cardiac arrhythmias. Gene- and cell-based therapies was evaluated. Gene- and cell-based therapies offer a potential paradigm shift away from traditional devices and drugs toward biologics for the treatment of cardiac rhythm disorders.