Mitochondrial haplogroup G1 was significantly more frequent in elite endurance/middle-power athletes compared to controls (OR 2.52), while haplogroup F was more frequent in sprint/power athletes (OR 2.79).
Case-Control (n=811)
Are specific mitochondrial haplogroups associated with elite athlete status in the Japanese population?
Mitochondrial haplogroups G1 and F are significantly associated with elite endurance/middle-power and sprint/power athlete status, respectively, in the Japanese population.
Effect estimate: OR 2.52 (95% CI 1.05 to 6.02)
Absolute Event Rate: 8.9% vs 3.7%
p-value: p=0.032
PURPOSE: It has been hypothesised that certain mitochondrial haplogroups, which are defined by the presence of a characteristic cluster of tightly linked mitochondrial DNA polymorphisms, would be associated with elite Japanese athlete status. To examine this hypothesis, the frequencies of mitochondrial haplogroups found in elite Japanese athletes were compared with those in the general Japanese population. METHODS: Subjects comprised 139 Olympic athletes (79 endurance/middle-power athletes (EMA), 60 sprint/power athletes (SPA)) and 672 controls (CON). Two mitochondrial DNA fragments containing the hypervariable sequence I (m16024-m16383) of the major non-coding region and the polymorphic site at m.5178C>A within the NADH dehydrogenase subunit 2 gene were sequenced, and subjects were classified into 12 major mitochondrial haplogroups (ie, F, B, A, N9a, N9b, M7a, M7b, M*, G2, G1, D5 or D4). The mitochondrial haplogroup frequency differences among EMA, SPA and CON were then examined. RESULTS: EMA showed an excess of haplogroup G1 (OR 2.52, 95% CI 1.05 to 6.02, p=0.032), with 8.9% compared with 3.7% in CON, whereas SPA displayed a greater proportion of haplogroup F (OR 2.79, 95% CI 1.28 to 6.07, p=0.007), with 15.0% compared with 6.0% in CON. CONCLUSIONS: The results suggest that mitochondrial haplogroups G1 and F are associated with elite EMA and SPA status in Japanese athletes, respectively.
Miyamoto‐Mikami et al. (Tue,) conducted a case-control in Elite athlete status (n=811). Mitochondrial haplogroup G1 vs. General Japanese population was evaluated on Frequency of mitochondrial haplogroup G1 in endurance/middle-power athletes (OR 2.52, 95% CI 1.05 to 6.02, p=0.032). Mitochondrial haplogroup G1 was significantly more frequent in elite endurance/middle-power athletes compared to controls (OR 2.52), while haplogroup F was more frequent in sprint/power athletes (OR 2.79).