April 26, 2010Open Access

Metabolic syndrome abnormalities are associated with severity of anxiety and depression and with tricyclic antidepressant use

Q: What is the clinical evidence from this study?

Study design: Case-Control. Population: Depression and/or anxiety (n=1846). Intervention: Very severe depression and tricyclic antidepressant (TCA) use vs. Controls and non-TCA users. Primary outcome: Prevalence of the metabolic syndrome (MetSyn) (OR 2.21, 95% CI 1.06-4.64, p=0.04).

Key Result

Very severe depression (OR 2.21; 95% CI 1.06-4.64) and tricyclic antidepressant use (OR 2.30; 95% CI 1.21-4.36) were significantly associated with increased odds of metabolic syndrome.

Study Design

Type

Case-Control (n=1,846)

Structured PICO

Are depression/anxiety severity and tricyclic antidepressant use associated with an increased prevalence of metabolic syndrome?

Population

1,217 depressed and/or anxious subjects and 629 controls

Intervention

Depression/anxiety symptom severity and tricyclic antidepressant (TCA) use

Comparator

Healthy controls and non-TCA users

Outcome

Prevalence of metabolic syndrome (MetSyn) and its components

Severe depression and tricyclic antidepressant use are significantly associated with an increased risk of metabolic syndrome, driven primarily by abdominal obesity and dyslipidemia.

Main Result

Effect estimate: OR 2.21 (95% CI 1.06-4.64)

p-value: p=0.04

Abstract

OBJECTIVE: The metabolic syndrome (MetSyn) predisposes to cardiovascular disease and diabetes mellitus. There might also be an association between the MetSyn and anxiety and depression, but its nature is unclear. We aimed to investigate whether diagnosis, symptom severity and antidepressant use are associated with the MetSyn. METHOD: We addressed the odds for the MetSyn and its components among 1217 depressed and/or anxious subjects and 629 controls, and their associations with symptom severity and antidepressant use. RESULTS: Symptom severity was positively associated with prevalence of the MetSyn, adjusted odds ratio (OR) 2.21 for very severe depression: 95% confidence interval (CI): 1.06-4.64, P = 0.04, which could be attributed to abdominal obesity and dyslipidemia. Tricyclic antidepressant (TCA) use also increased odds for the MetSyn (OR 2.30, 95% CI: 1.21-4.36, P = 0.01), independent of depression severity. CONCLUSION: The most severely depressed people and TCA users more often have the MetSyn, which is driven by abdominal adiposity and dyslipidemia.

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Cite This Study

Dortland et al. (Mon,) conducted a case-control in Depression and/or anxiety (n=1,846). Very severe depression and tricyclic antidepressant (TCA) use vs. Controls and non-TCA users was evaluated on Prevalence of the metabolic syndrome (MetSyn) (OR 2.21, 95% CI 1.06-4.64, p=0.04). Very severe depression (OR 2.21; 95% CI 1.06-4.64) and tricyclic antidepressant use (OR 2.30; 95% CI 1.21-4.36) were significantly associated with increased odds of metabolic syndrome.

synapsesocial.com/papers/6a1099d32badbc352a005ab8 https://doi.org/https://doi.org/10.1111/j.1600-0447.2010.01565.x

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