Bepridil and dl-sotalol produced similar electropharmacological effects in halothane-anesthetized dogs, including prolonged atrial and ventricular effective refractory periods, although their potencies varied.
Does bepridil have similar electropharmacological effects compared to dl-sotalol in halothane-anesthetized dogs?
Bepridil and dl-sotalol exhibit similar electropharmacological profiles in vivo, though with varying potencies for specific cardiovascular variables, which may guide drug selection based on patient pathophysiology.
BACKGROUND: Bepridil is known to have a multiple ion channel-blocking property in the heart, which has been applied for the treatment of atrial fibrillation and drug-refractory ventricular tachyarrhythmias. In this study, the electro-pharmacological effects of bepridil were compared with those of dl-sotalol, a representative class III antiarrhythmic drug, using the halothane-anesthetized canine model. METHODS AND RESULTS: Cardiovascular and electrophysiological variables were measured under the halothane anesthesia. Intravenous administration of bepridil (0.3 mg/kg, n=4) delayed the intraventricular conduction and prolonged the ventricular effective refractory period, whereas dl-sotalol (0.3 mg/kg, iv, n=4) inhibited atrioventricular conduction and prolonged the atrial and ventricular effective refractory period. The additional administration of 10 times the higher dose of bepridil or dl-sotalol (ie, 3 mg/kg, iv, n=4 for each group) decreased blood pressure, suppressed ventricular contraction and sinus automaticity, and prolonged the atrial and ventricular effective refractory period and monophasic action potential duration, in addition to the effects of the low dose. CONCLUSIONS: The electropharmacological effects of bepridil and dl-sotalol were similar, although their potency for each cardiovascular variable varied significantly. These findings can be useful when selecting these drugs according to the pathophysiological condition of a patient.
Ishizaka et al. (Tue,) conducted a other in Healthy animal model (electropharmacological evaluation) (n=8). Bepridil vs. dl-sotalol (0.3 mg/kg followed by 3 mg/kg intravenously) was evaluated on Cardiovascular and electrophysiological variables (e.g., MAP90, effective refractory periods). Bepridil and dl-sotalol produced similar electropharmacological effects in halothane-anesthetized dogs, including prolonged atrial and ventricular effective refractory periods, although their potencies varied.