Quantification of myocardial area at risk by T2-weighted CMR in reperfused AMI patients varied significantly between four different T2-weighted sequences (P < 0.05).
Observational (n=30)
Do different T2-weighted CMR sequences yield comparable assessments of myocardial area-at-risk and salvage area in patients with reperfused acute myocardial infarction?
Different T2-weighted CMR sequences yield significantly different quantifications of myocardial area-at-risk and salvage area in reperfused AMI, highlighting the need for standardization in imaging protocols.
p-value: p=< 0.05
PURPOSE: To compare different state-of-the-art T2-weighted (T2w) imaging sequences combined with late gadolinium enhancement (LGE) for myocardial salvage area (MSA) assessment by cardiac magnetic resonance (CMR). T2w imaging has been used to assess the myocardial area at risk (AAR) in acute myocardial infarction (AMI) patients, but its clinical application is challenging due to technical and physical limitations. MATERIALS AND METHODS: Thirty patients with reperfused AMI underwent complete CMR imaging 2-5 days after hospital admission. Myocardial AAR and MSA were quantified on four different T2w sequences: (a) free-breathing T2-prepared single-shot balanced steady-state free precession (T2pₛsbSSFP) ; (b) breathhold T2-weighted acquisition for cardiac unified T2 edema (ACUTE) ; (c) breathhold T2w dark-blood inversion recovery turbo-spin echo (IR-TSE) (short-term inversion recovery: STIR) ; and (d) free-breathing high-resolution T2 dark-blood navigated BLADE. The diagnostic performance of each technique was also assessed. RESULTS: Quantitative analysis showed significant differences in myocardial AAR extent as quantified by the four T2w sequences (P < 0. 05). There were also significant differences in sensitivity, specificity and overall diagnostic performance. CONCLUSION: Detection and quantification of AAR, and thus of MSA, by T2wCMR in reperfused AMI patients varied significantly between different T2w sequences in the same clinical setting.
Viallon et al. (Thu,) conducted a observational in reperfused acute myocardial infarction (n=30). T2-weighted (T2w) imaging sequences (T2p_ssbSSFP, ACUTE, STIR, BLADE) vs. Comparison among the four sequences was evaluated on Myocardial area at risk (AAR) extent (p=< 0.05). Quantification of myocardial area at risk by T2-weighted CMR in reperfused AMI patients varied significantly between four different T2-weighted sequences (P < 0.05).