Acute exercise increased flow-mediated dilation by 24% in active overweight men (P=0.034) but decreased it by 32% in inactive overweight men (P=0.010).
RCT (n=16)
mixed factorial
Does acute exercise affect flow-mediated dilation differently in active versus inactive overweight men?
Acute exercise enhances endothelial function in active overweight men but attenuates it in inactive overweight men, independent of exercise intensity.
Absolute Event Rate: 24% vs -32%
p-value: p=0.034 (active), 0.010 (inactive)
OBJECTIVE: Inflammation has been found to play a role in the etiology of cardiovascular disease as well as provoke endothelial dysfunction. Inflammatory cytokines associated with endothelial function are interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha). IL-6 is exercise intensity dependent and has been shown to inhibit TNF-alpha expression directly. The aim of this study was to investigate the interaction of IL-6 and TNF-alpha on endothelial function in response to acute exercise in overweight men exhibiting different physical activity profiles. METHODS AND PROCEDURES: Using a randomized mixed factorial design, 16 overweight men (8 active, maximal exercise capacity (VO(2)peak) = 34.2 +/- 1.7, BMI = 27.4 +/- 0.7 and 8 inactive, VO(2)peak = 30.9 +/- 1.2, BMI = 29.3 +/- 1.0) performed three different intensity acute exercise treatments. Brachial artery flow-mediated dilation (FMD) and subsequent blood samples were taken pre-exercise and 1 h following the cessation of exercise. RESULTS: Independent of exercise intensity, the active group displayed a 24% increase (P = 0.034) in FMD following acute exercise compared to a 32% decrease (P = 0.010) in the inactive group. Elevated (P < 0.001) concentrations of IL-6 following moderate (50% VO(2)) and high (75% VO(2)) intensity acute exercise were observed in both groups; however, concentrations of TNF-alpha were unchanged in response to acute exercise (P = 0.584). DISCUSSION: The FMD response to acute exercise is enhanced in active men who are overweight, whereas inactive men who are overweight exhibit an attenuated response. The interaction of IL-6 and TNF-alpha did not provide insight into the physiological mechanisms associated with the disparity of FMD observed between groups.
Harris et al. (Thu,) conducted a rct in Overweight (n=16). Acute exercise treatments vs. Inactive overweight men was evaluated on Brachial artery flow-mediated dilation (FMD) 1 h following the cessation of exercise (p=0.034 (active), 0.010 (inactive)). Acute exercise increased flow-mediated dilation by 24% in active overweight men (P=0.034) but decreased it by 32% in inactive overweight men (P=0.010).