Ga-68-FAPI-46-PET/MR imaging demonstrated ongoing fibroblast activation in 100% of patients at a mean of 30.9 days after acute myocardial infarction.
Observational (n=11)
Does Ga-68-FAPI-46-PET/MR imaging detect ongoing fibroblast activation in patients after acute myocardial infarction?
Ga-68-FAPI-46-PET/MR imaging demonstrates ongoing fibroblast activation in the delayed phase after acute myocardial infarction, providing insights into myocardial remodeling.
Purpose of the Report: Ga-Fibroblast-Activation Protein-alpha inhibitor (FAPI) positron-emission tomography (PET) and cardiac magnetic resonance imaging (MRI) constitute a novel diagnostic tool in patients for the assessment of myocardial damage after an acute myocardial infarction (AMI). Purpose of this pilot study was to evaluate simultaneous Ga-68-FAPI-46-PET/MR imaging in the delayed phase after AMI. Material and Methods: Ga-FAPI-46 PET/MRI post AMI. Standardized uptake values and fibroblast activation volume (FAV) were calculated and correlated with serum biomarkers and MRI parameters. Results: Ga-FAPI-46 uptake could be demonstrated in 11 (100 %) patients after a mean period of 30.9 ± 22.0 days. FAV significantly exceeded the infarction size in MRI and showed a good correlation to MRI parameters as well as to serum biomarkers of myocardial damage. Conclusions: Ga-FAPI-46 PET/MRI offers molecular and morphological imaging of affected myocardium after AMI. This study demonstrates ongoing fibroblast activation in a delayed phase after AMI and generates hypotheses for future studies while aiming for a better understanding of myocardial remodeling following ischemic tissue damage.
Kupusović et al. (2024) conducted an observational in Acute myocardial infarction (AMI) (n=11). Ga-68-FAPI-46-PET/MR imaging was evaluated on Ga-FAPI-46 uptake. Ga-68-FAPI-46-PET/MR imaging demonstrated ongoing fibroblast activation in 100% of patients at a mean of 30.9 days after acute myocardial infarction.