What question did this study set out to answer?

To compare the effects of no treatment, oestrogen, and calcium on bone loss in postmenopausal women.

September 24, 1977Open Access

Prospective trial of oestrogen and calcium in postmenopausal women.

Key Points

To compare the effects of no treatment, oestrogen, and calcium on bone loss in postmenopausal women.
Prospective trial involving 72 postmenopausal women
Follow-up period of at least two years
Densitometric and morphometric examinations conducted to assess bone changes.
Untreated group lost bone over two years
Oestrogen-treated group showed no bone loss
Calcium-treated group experienced intermediate loss.

Abstract

In a prospective trial in 72 postmenopausal women to compare the effects on bone loss of no treatment, treatment with oestrogen, and treatment with calcium the women were followed up for at least two years and examined densitometrically and morphometrically. Women in the untreated control group continued to lose bone during the two years, whereas the oestrogen-treated group lost none. Loss in the calcium-treated group was intermediate. Oestrogen appeared to inhibit endosteal bone resorption and may have stimulated subperiosteal bone apposition.

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Cite This Study

Horsman et al. (Sat,) studied this question.

synapsesocial.com/papers/6a11d84002d9c5b08421a4eb https://doi.org/https://doi.org/10.1136/bmj.2.6090.789

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