Dietary vitamin A restriction in rats after myocardial infarction intensified adverse ventricular remodeling, evidenced by higher diastolic left ventricular area (2.15 vs 1.81 cm2/kg; p=0.03).
Does dietary vitamin A restriction worsen ventricular remodeling in rats after experimental myocardial infarction?
Local tissue vitamin A insufficiency intensifies adverse ventricular remodeling and worsens diastolic dysfunction after myocardial infarction in a rat model.
Absolute Event Rate: 2.15% vs 1.81%
p-value: p=0.03
BACKGROUND/AIMS: The role of tissue vitamin-A insufficiency on post-infarction ventricular remodeling is unknown. We tested the hypothesis that cardiac vitamin A insufficiency on post-infarction is associated with adverse myocardial remodeling. METHODS: After infarction, rats were allocated into two groups: C (controls, n=25); VA (dietary vitamin A restriction, n= 26). After 3 months, the animals were submitted to echocardiogram, morphometric and biochemical analysis. RESULTS: Rats fed the vitamin-A-deficient diet had lower heart and liver retinol concentration and normal plasma retinol. There were no differences in infarct size between the groups. VA showed higher diastolic left ventricular area normalised by body weight (C= 1.81 ± 0.4 cm2/kg, VA= 2.15 ± 0.3 cm2/kg; p=0.03), left ventricular diameter (C= 9.4 ± 1.4 mm, VA= 10.5 ± 1.2 mm; p=0.04), but similar systolic ventricular fractional area change (C= 33.0 ± 10.0 %, VA= 32.1 ± 8.7 %; p=0.82). VA showed decreased isovolumetric relaxation time normalised by heart rate (C= 68.8 ± 11.4 ms, VA= 56.3 ± 16.8 ms; p=0.04). VA showed higher interstitial collagen fraction (C= 2.8 ± 0.9 %, VA= 3.7 ± 1.1 %; p=0.05). There were no differences in myosin heavy chain expression, metalloproteinase 2 and 9 activation, or IFN-γ and TNF-α cardiac levels. CONCLUSION: Local tissue vitamin A insufficiency intensified ventricular remodeling after MI, worsening diastolic dysfunction.
Minicucci et al. (Fri,) conducted a other in Myocardial Infarction (n=51). Dietary vitamin A restriction vs. Control diet was evaluated on Diastolic left ventricular area normalised by body weight (p=0.03). Dietary vitamin A restriction in rats after myocardial infarction intensified adverse ventricular remodeling, evidenced by higher diastolic left ventricular area (2.15 vs 1.81 cm2/kg; p=0.03).