A genetic risk score for coronary artery disease, independent of classical risk factors, was associated with a 24% higher risk of recurrence (HR 1.24) per standard deviation increase in patients.
Meta-Analysis (n=496)
Yes
Does a genetic risk score for coronary artery disease improve risk prediction for recurrences and cardiovascular mortality in patients with a first myocardial infarction?
A 12-variant genetic risk score for coronary artery disease improves risk reclassification for recurrent events and cardiovascular mortality in patients with a first myocardial infarction.
Effect estimate: HR 1.24 (95% CI 1.04-1.47)
Aim: This study aimed to evaluate the capacity of a genetic risk score (GRS) for coronary artery disease (CAD) independent of classical cardiovascular risk factors to assess the risk of recurrence in patients with first myocardial infarction. The secondary aim was to determine the predictive value of this GRS. Methods: We performed a meta-analysis of individual data from three studies, namely, a prospective study including 75 patients aged <55 years, a prospective study including 184 patients with a mean age of 60.5 years, and a case-control study (77 cases and 160 controls) nested in a cohort of patients with first myocardial infarction. A GRS including 12 CAD genetic variants independent of classical cardiovascular risk factors was developed. The outcome was a composite of cardiovascular mortality and recurrent acute coronary syndrome. Results: The GRS was associated with a higher risk of recurrence hazard ratio = 1.24; 95% confidence interval (CI): 1.04-1.47. The inclusion of the GRS in the clinical model did not increase the model's discriminative capacity (change in C-statistic/area under the curve: 0.009; 95% CI: -0.007 to 0.025) but improved its reclassification (continuous net reclassification index: 0.29; 95% CI: 0.08-0.51). Conclusion: The GRS for CAD, independent of classical cardiovascular risk factors, was associated with a higher risk of recurrence in patients with first myocardial infarction. The predictive capacity of this GRS identified a subgroup of high-risk patients who could benefit from intensive preventive strategies.
Rincon et al. (Thu,) conducted a meta-analysis in First myocardial infarction (n=496). Genetic risk score (GRS) for CAD vs. Clinical model without GRS was evaluated on Composite of cardiovascular mortality and recurrent acute coronary syndrome (HR 1.24, 95% CI 1.04-1.47). A genetic risk score for coronary artery disease, independent of classical risk factors, was associated with a 24% higher risk of recurrence (HR 1.24) per standard deviation increase in patients.
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