Network Pharmacological Study of Banxia Xiexin Decoction in the Treatment of Functional Dyspepsia with Liver Depression and Spleen Deficiency Type

Key Points

• This research aims to uncover the potential mechanisms and targets of Banxia Xiexin Decoction in treating functional dyspepsia with liver depression and spleen deficiency.
• Mapped active components of Banxia Xiexin Decoction to target proteins related to functional dyspepsia using TCMSP and Pubchem databases.
• Identified relevant disease targets through GeneCards and Venny 2.1.0 platform for common target analysis.
• Constructed a 'component-target-disease' network using Cytoscape and performed GO and KEGG pathway enrichment analyses via Metascape.
• Identified 1,014 potential action targets for Banxia Xiexin Decoction and 500 disease-related targets, with 151 overlapping targets.
• Highlighted key active components such as ephedrine, berberine, baicalin, and baicalein as effective in treatment.
• Proposed that the decoction may regulate pathways involving IL-6, BCL2, STAT3, EGFR, and HIF1A to exert anti-inflammatory effects and enhance gastrointestinal motility.