In a computational model of the left atrium, varying myocardial fiber organization had little effect on the spatio-temporal activation pattern during regular pacing, with an average local activation time error of 7.8 ms.
Computational modeling demonstrates that myocardial fiber organization has a minimal effect on macroscopic electrical activation patterns in the left atrium, suggesting that clinically practical, fiber-independent patient-specific models may be feasible.
Over the past two decades there has been a steady trend towards the development of realistic models of cardiac conduction with increasing levels of detail. However, making models more realistic complicates their personalization and use in clinical practice due to limited availability of tissue and cellular scale data. One such limitation is obtaining information about myocardial fiber organization in the clinical setting. In this study, we investigated a chimeric model of the left atrium utilizing clinically derived patient-specific atrial geometry and a realistic, yet foreign for a given patient fiber organization. We discovered that even significant variability of fiber organization had a relatively small effect on the spatio-temporal activation pattern during regular pacing. For a given pacing site, the activation maps were very similar across all fiber organizations tested.
He et al. (Fri,) conducted a other in Focal arrhythmias in the left atrium (n=7). Chimeric models with foreign fiber organization vs. Ground-truth model with intrinsic fiber organization was evaluated on Local Activation Time (LAT) error. In a computational model of the left atrium, varying myocardial fiber organization had little effect on the spatio-temporal activation pattern during regular pacing, with an average local activation time error of 7.8 ms.
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