Abstract This study aimed to assess the impact of ten sessions of major ozone therapy on disease severity and ophthalmologic parameters in patients with fibromyalgia syndrome (FMS). This observational study was conducted in the Physical Medicine and Rehabilitation and Ophthalmology clinics of a tertiary healthcare facility. The study involved 30 patients diagnosed with FMS who underwent 10 weekly sessions of major ozone therapy. Symptom severity was measured before and after treatment using the Fibromyalgia Impact Scale (FIQ). The study assessed ophthalmic parameters, including visual acuity, spherical equivalent, astigmatism, axis, intraocular pressure, and central corneal thickness. Additionally, microvascular changes were examined using optical coherence tomography angiography (OCTA). Post-treatment, FIQ scores decreased significantly (before: 67.19 ± 14.02; after: 46.78 ± 11.46; p 0.05). Ten sessions of major ozone therapy effectively reduced symptom burden in FMS patients, though short-term changes in the anterior segment and retinal microvascular structures were not measurable. Ozone therapy may serve as a complementary and supportive approach alongside existing treatments for managing FMS.
Koçyiğit et al. (Sat,) studied this question.