Nonadherence to clinical practice guidelines significantly increased the risk of target organ damage in hypertensive patients (AOR 1.636; 95% CI 1.189-2.251).
Cohort (n=612)
Open-label
No
Does nonadherence to clinical practice guidelines increase target organ damage in hypertensive patients?
Nonadherence to clinical practice guidelines significantly increases the risk of target organ damage in hypertensive patients.
Effect estimate: AOR 1.636 (95% CI 1.189-2.251)
p-value: p=0.01
Background . There was limited published data on target organ damage (TOD) and the effect of nonadherence to practice guidelines in Ethiopia. This study determined TOD and the long term effect of nonadherence to clinical guidelines on hypertensive patients. Methods . An open level retrospective cohort study has been employed at cardiac clinic of Gondar university hospital for a mean follow-up period of 78 months. Multivariate Cox regression was conducted to test associating factors of TOD. Results . Of the total number of 612 patients examined, the overall prevalence of hypertensive TOD was 40.3%. The presence of comorbidities, COR = 1.073 1.01–1.437, AOR = 1.196 1.174–1.637, and nonadherence to clinical practice guidelines, COR = 1.537 1.167–2.024, AOR = 1.636 1.189–2.251, were found to be predicting factors for TOD. According to Kaplan-Meier analysis patients who were initiated on appropriate medication tended to develop TOD very late: Log Rank 11.975 (p=0.01). Conclusion . More than forty percent of patients acquired TOD which is more significant. Presence of comorbidities and nonadherence to practice guidelines were correlated with the incidence of TOD. Appropriate management of hypertension and modification of triggering factors are essential to prevent complications.
Abegaz et al. (Sun,) conducted a cohort in Hypertension (n=612). Nonadherence to clinical practice guidelines vs. Adherence to clinical practice guidelines was evaluated on Target organ damage (TOD) (AOR 1.636, 95% CI 1.189-2.251, p=0.01). Nonadherence to clinical practice guidelines significantly increased the risk of target organ damage in hypertensive patients (AOR 1.636; 95% CI 1.189-2.251).