High frame rate cardiac cine MR-derived left ventricular diastolic function indices correlated well with E/A Q-flow (r2=0.66 and 0.54) and E/A echo (r2=0.58 and 0.49).
Observational (n=24)
No
Does high frame rate cardiac cine MRI accurately evaluate LV diastolic function compared to echocardiography in asymptomatic volunteers?
High frame rate cardiac cine MRI (>35 fps) can reliably extract LV diastolic function indices from temporal changes in LV volume, correlating well with traditional echocardiography.
Background Breath‐hold cine MR is the method of choice for evaluating left ventricular (LV) systolic function; however, the evaluation of diastolic function remains in the domain of high frame rate echocardiography. Thus, a cine MR technique for simultaneously evaluating LV systolic and diastolic function would be clinically valuable. Purpose To test the feasibility of extracting indices that characterize LV diastolic function from high frame rate cine MR. Study Type Single center, prospective. Population Asymptomatic volunteers ( N = 24; age 45.8 ± 12.3 years). Field Strength/Sequence High frame rate (70 fps) cine MR and phase‐contrast MR during free breathing were acquired at 1.5T. Assessment The following MR‐based LV filling metrics were extracted from LV volume changes during the cardiac cycle: 1) the volume–rate ratio, R EFP /R LFP (ratio of the peak LV filling rate during the early filling period EFP to that during the late filling period LFP); and 2) the volume ratio, V EFP /V LFP (the ratio of cumulative LV volume change between the EFP and LFP). These metrics were then compared with traditional transmitral blood flow‐based MR and echocardiographic indices. The effect of temporal resolution on these metrics was also evaluated. Statistical Tests Bland–Altman and linear regression analyses were used to evaluate the performance of the proposed metrics against traditional indices of diastolic function. Results The R EFP /R LFP and V EFP /V LFP correlated well with E/A Q‐flow ( r 2 = 0.66 and 0.54, respectively) and E/A echo ( r 2 = 0.58 and 0.49, respectively). Systolic indices remained robust (8% error) for frame rates below 35 fps. Data Conclusion In asymptomatic volunteers, cardiac cine MR images acquired at frame rates >35 fps can be used to extract LV diastolic function indices from the temporal changes in LV volume. Level of Evidence: 1 Technical Efficacy Stage: 1 J. Magn. Reson. Imaging 2019;50:1571–1582.
Zhang et al. (Tue,) conducted a observational in Asymptomatic volunteers (n=24). High frame rate cardiac cine MR vs. Echocardiography and phase-contrast MR was evaluated on Correlation of volume-rate ratio (REFP/RLFP) and volume ratio (VEFP/VLFP) with traditional indices. High frame rate cardiac cine MR-derived left ventricular diastolic function indices correlated well with E/A Q-flow (r2=0.66 and 0.54) and E/A echo (r2=0.58 and 0.49).