Caffeine intake >100 mg/d in African American adolescents was associated with higher systolic blood pressure compared to 0-50 mg/d (mean difference 6.0 mm Hg; 95% CI 2.3-9.7; P=0.001).
Observational (n=159)
Does higher caffeine intake increase blood pressure in African American and white adolescents?
High caffeine intake (>100 mg/d) is associated with significantly higher systolic blood pressure in African American adolescents.
Effect estimate: mean difference 6.0 mm Hg (95% CI 2.3 to 9.7)
p-value: p=.001
OBJECTIVE: To assess the association between the consumption of caffeinated beverages and blood pressure in African American and white adolescents. DESIGN: This study was part of ongoing research examining stress-induced hemodynamic responses in adolescents. African American and white adolescents (n = 159) selected foods and beverages for a 3-day sodium-controlled diet. Caffeine in these foods was used to stratify participants into 3 categories (0-50 mg/d, >50-100 mg/d, and >100 mg/d). Before menu selection, blood pressure readings were obtained. STATISTICAL ANALYSIS: A general linear model (multiple regression with both categorical and continuous variables) was developed to assess the effects of race, category of caffeine intake, and interaction of race and caffeine intake on systolic and diastolic blood pressure controlling for sex and body mass index (calculated as weight in kilograms divided by height in meters squared). RESULTS: The association between systolic blood pressure and caffeine category varied by race (P =.001). African Americans consuming more than 100 mg/d of caffeine had higher systolic blood pressure readings than the groups consuming 0 to 50 mg/d (mean difference, 6.0 mm Hg; 95% confidence interval CI, 2.3 to 9.7) or more than 50 to 100 mg/d (mean difference, 7.1 mm Hg; 95% CI, 3.4 to 10.7). The effect on diastolic blood pressure was less pronounced (P =.08). The diastolic blood pressure of the group consuming more than 100 mg/d was 3.7 mm Hg (95% CI, 0.41 to 7.0) higher than the group consuming more than 50 to 100 mg/d and was not statistically different from the group consuming 0 to 50 mg/d (mean difference, 2.4 mm Hg; 95% CI, -0.9 to 5.8). There was no evidence that the association between diastolic blood pressure and caffeine intake varied by race (P =.80). CONCLUSIONS: For adolescents, especially African American adolescents, caffeine intake may increase blood pressure and thereby increase the risk of hypertension. Alternatively, caffeinated drink consumption may be a marker for dietary and lifestyle practices that together influence blood pressure. Additional research is needed owing to rising rates of adolescent hypertension and soft drink consumption.
Savoca et al. (Sat,) conducted a observational in Blood pressure (n=159). Caffeine intake vs. 0-50 mg/d and >50-100 mg/d was evaluated on Systolic blood pressure (mean difference 6.0 mm Hg, 95% CI 2.3 to 9.7, p=.001). Caffeine intake >100 mg/d in African American adolescents was associated with higher systolic blood pressure compared to 0-50 mg/d (mean difference 6.0 mm Hg; 95% CI 2.3-9.7; P=0.001).
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