A data-driven biopsychosocial risk score predicted the development and spreading of widespread chronic pain across body sites over a 9-year period with an AUC of 0.68-0.78.
Cohort (n=493,211)
Does a biopsychosocial risk score predict the development and spread of chronic pain across body sites?
A biopsychosocial risk score based on common factors like mood, sleep, and BMI can predict the development and spread of chronic pain across body sites over a 9-year period.
Effect estimate: AUC 0.68-0.78
Abstract Chronic pain is a complex condition influenced by a combination of biological, psychological and social factors. Using data from the UK Biobank ( n = 493,211), we showed that pain spreads from proximal to distal sites and developed a biopsychosocial model that predicted the number of coexisting pain sites. This data-driven model was used to identify a risk score that classified various chronic pain conditions (area under the curve (AUC) 0.70–0.88) and pain-related medical conditions (AUC 0.67–0.86). In longitudinal analyses, the risk score predicted the development of widespread chronic pain, the spreading of chronic pain across body sites and high-impact pain about 9 years later (AUC 0.68–0.78). Key risk factors included sleeplessness, feeling ‘fed-up’, tiredness, stressful life events and a body mass index >30. A simplified version of this score, named the risk of pain spreading, obtained similar predictive performance based on six simple questions with binarized answers. The risk of pain spreading was then validated in the Northern Finland Birth Cohort ( n = 5,525) and the PREVENT-AD cohort ( n = 178), obtaining comparable predictive performance. Our findings show that chronic pain conditions can be predicted from a common set of biopsychosocial factors, which can aid in tailoring research protocols, optimizing patient randomization in clinical trials and improving pain management.
Tanguay-Sabourin et al. (Sat,) conducted a cohort in Chronic pain (n=493,211). Biopsychosocial risk score (Risk of pain spreading) was evaluated on Development and spreading of widespread chronic pain (AUC 0.68-0.78). A data-driven biopsychosocial risk score predicted the development and spreading of widespread chronic pain across body sites over a 9-year period with an AUC of 0.68-0.78.