Genetically predicted 1-SD increase in educational attainment reduced the risk of atrial fibrillation by 19% (OR 0.81), independent of intelligence and cognition.
Observational (n=1,292,231)
Mendelian randomization
Yes
Does genetically predicted higher socioeconomic status, intelligence, and cognition reduce the risk of atrial fibrillation in individuals of European ancestry?
Higher educational attainment has a causal, protective effect against atrial fibrillation, which is largely mediated by modifiable cardiometabolic risk factors like heart failure and obesity.
Effect estimate: OR 0.81 (95% CI 0.71-0.92)
p-value: p=<0.05
BACKGROUND: Lower socioeconomic status, intelligence, and cognition are linked to a higher likelihood of atrial fibrillation (AF). However, whether these factors directly cause AF or whether others mediate this relationship is unclear. OBJECTIVES: Our study aimed to determine the causal link between lower socioeconomic status, intelligence, cognition, and AF, and identify mediators. METHODS: We conducted a 2-sample Mendelian randomization analysis with data from European ancestry genome-wide association studies. Genetic instruments for education, intelligence, cognition, income, and occupation (n = 248,847-1,131,881) evaluated their relationship with AF (FinnGen study: 50,743 cases and 210,652 control subjects; 6 European studies: 60,620 and 970,216). RESULTS: The pooled results from meta-analysis combining data from 2 studies indicated that education, intelligence, and cognition were causally associated with AF (P < 0.05). Genetically predicted, each 1-SD increase in educational attainment was associated with a 19% decreased risk of AF (OR: 0.81; 95% CI: 0.71-0.92), independent of intelligence and cognition. Among 44 candidate mediators, 8 factors were identified to mediate the education-AF association, including heart failure (mediation proportion: 95.35%), body fat mass (44.05%), waist circumference (42.93%), coronary heart disease (30.1%), body mass index (29.0%), myocardial infarction (28.8%), diastolic blood pressure (21.7%), and waist-to-hip ratio (14.3%). CONCLUSIONS: Our study suggests that education exerts a causal and protective effect against AF, independent of intelligence and cognition. Heart failure, obesity, and ischemic heart disease serve as mediating factors in the pathway from education to AF, underscoring the importance of considering these conditions in preventing AF associated with education inequality.
Kaisaier et al. (Tue,) conducted a observational in Atrial Fibrillation (n=1,292,231). Genetically predicted educational attainment vs. Lower educational attainment was evaluated on Risk of atrial fibrillation (OR 0.81, 95% CI 0.71-0.92, p=<0.05). Genetically predicted 1-SD increase in educational attainment reduced the risk of atrial fibrillation by 19% (OR 0.81), independent of intelligence and cognition.