Metabolic syndrome was associated with an increased risk of carotid plaques (OR 1.16; 95% CI 1.03-1.30) and higher average carotid intima-media thickness (β = 0.020; 95% CI 0.014-0.027).
Cross-Sectional (n=8,933)
Yes
Is metabolic syndrome associated with increased carotid atherosclerosis in Chinese adults aged 40 years or older?
Metabolic syndrome is significantly associated with increased carotid intima-media thickness and the presence of carotid plaques in Chinese adults over 40.
Effect estimate: OR 1.16 (95% CI 1.03-1.30)
OBJECTIVE: Increased carotid artery intima-media thickness (CIMT) and carotid plaque as manifestations of carotid atherosclerosis have been used as markers of cardiovascular disease (CVD). The components of metabolic syndrome (MetS) are linked to CVD, but the association between MetS and CVD is controversial. METHODS: A total of 8,933 Chinese adults aged 40 years or older from 2010 to 2014 were selected from the Jidong and Kailuan communities. MetS was defined by the International Diabetes Federation criteria. CIMT and carotid plaque were measured using color Doppler ultrasound. Logistic regression models were used to assess the association of MetS with carotid plaque and CIMT. RESULTS: MetS was found among 3,461 (3,461/8,933) participants. The odds ratio and 95% confidence internal (CI) for carotid plaques in participants with MetS was 1.16 (1.03-1.30). The risk of carotid plaques increased with the number of MetS components. The average CIMT was higher in participants with MetS (β = 0.020, 95% CI, 0.014-0.027) and in participants with more MetS components. CONCLUSION: Individuals with MetS are at an increased risk for carotid atherosclerosis compared to those without MetS.
Zhou et al. (Sun,) conducted a cross-sectional in Metabolic Syndrome and Carotid Atherosclerosis (n=8,933). Metabolic syndrome vs. No metabolic syndrome was evaluated on Carotid plaques (OR 1.16, 95% CI 1.03-1.30). Metabolic syndrome was associated with an increased risk of carotid plaques (OR 1.16; 95% CI 1.03-1.30) and higher average carotid intima-media thickness (β = 0.020; 95% CI 0.014-0.027).