Effective arterial elastance was less strongly associated with pulmonary vascular resistance (ρ=0.83, P<0.0001) than with total pulmonary arterial stiffness in patients with pulmonary hypertension.
Observational (n=236)
What is the main correlate of effective arterial elastance in adults with pre- and post-capillary pulmonary hypertension?
In patients with pulmonary hypertension, effective arterial elastance correlates most closely with pulmonary arterial stiffness rather than vascular resistance, suggesting right ventricular responses are primarily driven by pulsatile load.
Effect estimate: ρ=0.83
p-value: p=<0.0001
BACKGROUND: associated with worse prognosis. Although arterial elastance is thought to depend more on pulmonary vascular resistance (PVR) than on stiffness, the value of this simplified, clinically derived estimate remains unclear. METHODS: This retrospective invasive study included 236 adults diagnosed with idiopathic pulmonary arterial hypertension (n = 118) or post-capillary PH (n = 118), matched for age, sex, and mean PA pressure (mPAP). Total PA stiffness was defined as PA pulse pressure/SV. RESULTS: was less strongly associated with PVR (ρ=0.83) (P < 0.0001), with differing slopes and intercepts between groups. Similar results were observed when downstream pressure was included in elastance calculation, and in the youngest age tertile. CONCLUSIONS: most closely correlated with the PA pulse pressure/SV ratio, the standard clinical estimate of total PA stiffness. This overlap among clinical indices of PA load warrants recognition, suggesting right ventricular responses may be mainly driven by pulsatile load, with potential therapeutic implications.
Chemla et al. (Fri,) conducted a observational in Idiopathic pulmonary arterial hypertension or post-capillary pulmonary hypertension (n=236). Effective arterial elastance was less strongly associated with pulmonary vascular resistance (ρ=0.83, P<0.0001) than with total pulmonary arterial stiffness in patients with pulmonary hypertension.
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