Ablation of renin-b in mice exacerbated cardiac remodeling and modestly increased renal glomerular matrix deposition after 4 weeks of angiotensin II infusion compared with wild-type mice.
Does ablation of renin-b exacerbate Angiotensin II-induced cardiac and renal organ damage in mice?
Renin-b appears to play a protective role against hypertensive cardiac remodeling, suggesting it could be a potential therapeutic target for hypertensive heart disease.
Several cardiac and renal diseases are attributed to a dysregulation of the renin-angiotensin system. Renin, the rate-limiting enzyme of the renin-angiotensin system, has 2 isoforms. The classical renin isoform (renin-a) encoding preprorenin is mainly confined to the juxtaglomerular cells and released into the circulation upon stimulation. Alternatively, renin-b is predicted to remain intracellular and is expressed in the brain, heart, and adrenal gland. In the brain, ablation of renin-b (Ren-b Null mice) results in increased brain renin-angiotensin system activity. However, the consequences of renin-b ablation in tissues outside the brain remain unknown. Therefore, we hypothesized that renin-b protects from hypertensive cardiac and renal end-organ damage in mice. Ren-b Null mice exhibited normal blood pressure at baseline. Thus, we induced hypertension by using a slow pressor dose of Ang II (angiotensin II). Ang II increased blood pressure in both wild type and Ren-b Null to the same degree. Although the blood pressure between Ren-b Null and wild-type mice was elevated equally, 4-week infusion of Ang II resulted in exacerbated cardiac remodeling in Ren-b Null mice compared with wild type. Ren-b Null mice also exhibited a modest increase in renal glomerular matrix deposition, elevated plasma aldosterone, and a modestly enhanced dipsogenic response to Ang II. Interestingly, ablation of renin-b strongly suppressed plasma renin, but renal cortical renin mRNA was preserved. Altogether, these data indicate that renin-b might play a protective role in the heart, and thus renin-b could be a potential target to treat hypertensive heart disease.
Nakagawa et al. (Sat,) conducted a other in Hypertensive cardiac and renal end-organ damage. Renin-b ablation (Ren-b Null mice) with Angiotensin II infusion vs. Wild-type mice with Angiotensin II infusion was evaluated on Cardiac remodeling and renal glomerular matrix deposition. Ablation of renin-b in mice exacerbated cardiac remodeling and modestly increased renal glomerular matrix deposition after 4 weeks of angiotensin II infusion compared with wild-type mice.
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