Mouse Model of Graves’ Orbitopathy in Current Research and Future Perspectives

Key Points

• The aim is to explore current mouse models of Graves’ orbitopathy and discuss advancements in modeling strategies.
• Review of available mouse models for Graves’ orbitopathy.
• Analysis of recent experimental modeling strategies.
• Discussion of limitations in current in vitro studies using orbital fibroblasts.
• Identification of gaps in understanding the pathogenic mechanisms of Graves’ orbitopathy.
• Overview of the limitations of current animal models for effective in vivo investigation.
• Emphasis on the need for improved experimental modeling for future research.

Abstract