Hand hygiene remains one of the most effective preventive measures for reducing the transmission of infectious diseases in both healthcare and community settings. Human hands serve as major vectors for the spread of bacterial, viral, and fungal pathogens, making effective hand sanitization an essential public health intervention. The present study aimed to formulate and evaluate a polyherbal hand sanitizer incorporating extracts of Neem (Azadirachta indica), Tulsi (Ocimum sanctum), Aloe vera (Aloe barbadensis), and Mint (Mentha arvensis) as active botanical ingredients. These medicinal plants were selected based on their established antimicrobial, anti-inflammatory, antioxidant, antiviral, and skin-protective properties. The herbal hand sanitizer was formulated using a hydroalcoholic base containing isopropyl alcohol, glycerin, and distilled water as excipients. The prepared formulation was evaluated for physicochemical properties, skin compatibility, and short-term stability. The final formulation demonstrated acceptable organoleptic characteristics, including green appearance, pleasant odor, smooth texture, and acceptable consistency. Physicochemical evaluation showed a pH range of 5.5–7.0, bulk density of 0.75 g/mL, tapped density of 0.857 g/mL, and acceptable flow-related characteristics. Skin irritation testing demonstrated no visible erythema, itching, swelling, or discomfort, indicating favorable dermatological compatibility. Stability observations revealed no significant changes in color, odor, texture, or pH during the study period. The findings suggest that the developed polyherbal hand sanitizer may serve as a safe and cosmetically acceptable hygiene formulation with potential antimicrobial utility.
Kakade et al. (Mon,) studied this question.
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