Genetic factors play a complex, multifactorial role in the risk of developing acute coronary artery disease, with recent advances driven by whole genome scanning and genome-wide association studies.
What is the role of genetic factors in the risk of developing acute coronary artery disease?
This narrative review highlights the significant advances in understanding the genetic causes of acute coronary syndrome, primarily driven by genome-wide association studies.
Acute coronary artery syndrome in the leading cause of morbidity and mortality in Western countries, and its epidemiological burden is also constantly increasing worldwide, including Asia. Due to social and economic consequences, a number of experimental and epidemiological studies have analyzed its etiology so far, in order to develop effective preventive and treatment measures. Thanks to these studies, it is now clear that coronary artery disease (CAD) is a complex multifactorial disorder, resulting from close interaction between acquired and inherited risk factors. In particular, considerable advances were made in the last decade about our understanding of the genetic causes of CAD, mainly propelled by the progresses in whole genome scanning and the development of genome wide association studies. This narrative review is hence dedicated to explore the role of genetic factors in the risk of developing acute CAD.
Massimo Franchini (Sun,) conducted a review in Acute coronary syndrome. Genetic factors play a complex, multifactorial role in the risk of developing acute coronary artery disease, with recent advances driven by whole genome scanning and genome-wide association studies.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: