What is the clinical evidence from this study?

Study design: Observational. Population: Paroxysmal atrial fibrillation (n=224). Intervention: Low eGFR ( 60 ml/min/1.73 m2). Primary outcome: Recurrence of atrial fibrillation (p=0.006).

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November 9, 2010

Relationship between renal function and the risk of recurrent atrial fibrillation following catheter ablation

Q: What are the key findings of this study?

Low eGFR (<60 ml/min/1.73 m2) was associated with a significantly higher rate of recurrent atrial fibrillation following catheter ablation compared to high eGFR (24.3% vs 6.7%, p=0.006).

Q: What does this research mean for the field?

Low estimated glomerular filtration rate (<60 ml/min/1.73 m2) and left atrium dilatation are independent predictors of a significantly higher rate of recurrent atrial fibrillation following catheter ablation. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Key Result

Low eGFR (<60 ml/min/1.73 m2) was associated with a significantly higher rate of recurrent atrial fibrillation following catheter ablation compared to high eGFR (24.3% vs 6.7%, p=0.006).

Study Design

Type

Observational (n=224)

Structured PICO

Does baseline renal function predict the recurrence of atrial fibrillation following catheter ablation in patients with paroxysmal AF?

Population

224 patients with paroxysmal atrial fibrillation undergoing catheter ablation

Intervention

Catheter ablation in patients with low eGFR (<60 ml/min/1.73 m2)

Comparator

Patients with high eGFR (>60 ml/min/1.73 m2)

Outcome

Recurrence of atrial fibrillation

Low eGFR (<60 ml/min/1.73 m2) and left atrial dilatation are independent predictors of atrial fibrillation recurrence after catheter ablation for paroxysmal AF.

Main Result

Absolute Event Rate: 24.3% vs 6.7%

p-value: p=0.006

Abstract

BACKGROUND: Although several clinical variables are associated with the recurrence of atrial fibrillation (AF) following catheter ablation, the influence of renal function remains to be determined. OBJECTIVE: To evaluate the association of renal function with the outcome of the paroxysmal AF ablation. METHODS: 224 patients underwent catheter ablation for paroxysmal AF. The relationship between the pre-procedural clinical valuables and ablation outcomes was evaluated. RESULTS: Over the course of 37.4±24.4 months of follow-up of catheter ablation procedures for AF (mean number of procedures 1.33±0.45), 91.1% of patients (204/224) became free from AF without antiarrhythmic drugs. The estimated glomerular filtration rate (eGFR) was lower in patients with recurrent AF than in those without recurrence (66.6±17.5 vs 78.4±16.8 ml/min/1.73 m(2), p=0.003). AF recurred more frequently in patients with low eGFR (60 ml/min/1.73 m(2); 24.3% vs 6.7%, p=0.006). Among the various clinical factors, low eGFR (p=0.02) and left atrium (LA) dilatation (p=0.002) independently predicted the clinical outcome of ablation in patients with paroxysmal AF. CONCLUSION: Low eGFR and LA dilatation independently influence the outcome of catheter ablation for paroxysmal AF.

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Cite This Study

Tokuda et al. (Tue,) führten eine Beobachtungsstudie bei paroxysmaler Vorhofflimmern (n=224) durch. Geringe eGFR (<60 ml/min/1,73 m²) vs. hohe eGFR (>60 ml/min/1,73 m²) wurde in Bezug auf das Wiederauftreten von Vorhofflimmern (p=0,006) bewertet. Eine geringe eGFR (<60 ml/min/1,73 m²) war mit einer signifikant höheren Rate an wiederkehrendem Vorhofflimmern nach einer Katheterablation im Vergleich zur hohen eGFR assoziiert (24,3 % vs. 6,7 %, p=0,006).

synapsesocial.com/papers/6a171ee7c23c548e2a7bc6b1 https://doi.org/https://doi.org/10.1136/hrt.2010.200824

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