Elevated arterial stiffness at baseline was associated with a significantly increased risk of incident dyslipidemia compared to normal arterial stiffness (HR 1.194).
Cohort (n=4,362)
No
Does elevated arterial stiffness increase the risk of incident dyslipidemia in adults?
Elevated arterial stiffness is an independent predictor of incident dyslipidemia, suggesting a bidirectional relationship between vascular stiffness and lipid metabolism.
Effect estimate: HR 1.194 (95% CI 1.050-1.358)
Absolute Event Rate: 39% vs 29.3%
p-value: p=0.007
Background and aims: Dyslipidemia is known to contribute to arterial stiffness, while the inverse association remains unknown. This study aimed to explore the association of baseline arterial stiffness and its changes, as determined by brachial-ankle pulse wave velocity (baPWV), with dyslipidemia onset in the general population. Methods: This study enrolled participants from Beijing Health Management Cohort using measurements of the first visit from 2012 to 2013 as baseline, and followed until the dyslipidemia onset or the end of 2019. Unadjusted and adjusted Cox proportional regression models were used to evaluate the associations of baseline baPWV and baPWV transition (persistent low, onset, remitted and persistent high) with incident dyslipidemia. Results: Of 4362 individuals (mean age: 55.5 years), 1490 (34.2%) developed dyslipidemia during a median follow-up of 5.9 years. After adjusting for potential confounders, participants with elevated arterial stiffness at baseline had an increased risk of dyslipidemia (HR, 1.194; 95% CI, 1.050-1.358). Compared with persistent low baPWV, new-onset and persistent high baPWV were associated with a 51.2% and 37.1% excess risk of dyslipidemia. Conclusion: The findings indicated that arterial stiffness is an early risk factor of dyslipidemia, suggesting a bidirectional association between arterial stiffness and lipid metabolism.
Wang et al. (Thu,) conducted a cohort in Dyslipidemia (n=4,362). Elevated arterial stiffness (baPWV ≥1400 cm/s) vs. Normal arterial stiffness (baPWV <1400 cm/s) was evaluated on Incident dyslipidemia (HR 1.194, 95% CI 1.050-1.358, p=0.007). Elevated arterial stiffness at baseline was associated with a significantly increased risk of incident dyslipidemia compared to normal arterial stiffness (HR 1.194).