Chronic infusion of ANP in Dahl salt-sensitive rats attenuated the increase in blood pressure and cardiorenal damage induced by a high-salt diet.
Does ANP infusion or deficiency affect blood pressure and cardiorenal function in a rat model of salt-sensitive hypertension?
ANP deficiency exacerbates salt-sensitive hypertension and cardiorenal damage, while ANP supplementation attenuates these effects, suggesting therapeutic potential for ANP-increasing drugs in salt-sensitive hypertension.
p-value: p=<0.01
Atrial natriuretic peptide (ANP), encoded by Nppa, is a vasodilatory hormone that promotes salt excretion. Genome-wide association studies identified Nppa as a causative factor of blood pressure development, and in humans, ANP levels were suggested as an indicator of salt sensitivity. This study aimed to provide insights into the effects of ANP on cardiorenal function in salt-sensitive hypertension. To address this question, hypertension was induced in SSNPPA-/- (KO of Nppa in the Dahl salt-sensitive SS rat background) or SSWT (WT Dahl SS) rats by a high-salt (HS) diet challenge (4% NaCl for 21 days). Chronic infusion of ANP in SSWT rats attenuated the increase in blood pressure and cardiorenal damage. Overall, the SSNPPA-/- strain demonstrated higher blood pressure and intensified cardiac fibrosis (with no changes in ejection fraction) compared with SSWT rats. Furthermore, SSNPPA-/- rats exhibited kidney hypertrophy and higher glomerular injury scores, reduced diuresis, and lower sodium and chloride excretion than SSWT when fed a HS diet. Additionally, the activity of epithelial Na+ channel (ENaC) was found to be increased in the collecting ducts of the SSNPPA-/- rats. Taken together, these data show promise for the therapeutic benefits of ANP and ANP-increasing drugs for treating salt-sensitive hypertension.
Ilatovskaya et al. (Tue,) conducted a other in Salt-sensitive hypertension. Atrial natriuretic peptide (ANP) infusion vs. Vehicle (saline) was evaluated on Mean arterial pressure (MAP) (p=<0.01). Chronic infusion of ANP in Dahl salt-sensitive rats attenuated the increase in blood pressure and cardiorenal damage induced by a high-salt diet.