Alcohol intoxication was associated with a significantly increased risk of deep vein thrombosis (HR 3.40) and pulmonary embolism (HR 3.53) compared to non-intoxicated controls.
Cohort (n=306,145)
Does acute alcohol intoxication increase the risk of newly diagnosed deep vein thrombosis or pulmonary embolism in adults?
Acute alcohol intoxication requiring hospitalization is independently associated with a more than 3-fold increased risk of subsequent deep vein thrombosis and pulmonary embolism.
Effect estimate: HR 3.40 (95% CI 2.83-4.08)
Absolute Event Rate: 9.36% vs 2.07%
p-value: p=<0.001
This study investigated whether alcohol intoxication (AI) increases the risk of venous thromboembolism (VTE) by using the Taiwan National Health Insurance Research Database (NHIRD).Using data from the NHIRD, we assembled 61,229 patients with acute AI and randomly selected 244,916 controls. Each patient was monitored from 2000 to 2011 to identify those who were subsequently diagnosed with deep vein thrombosis (DVT) and pulmonary embolism (PE). Cox proportional hazard regression analysis was conducted to determine the risk of VTE in the patients with AI compared with the controls.The incidence rate of DVT during the 10 years follow-up period was 9.36 per 10,000 person-years and 2.07 per 10,000 person-years in the AI and non-AI cohorts, respectively. Moreover, the incidence rate of PE was 4 per 10,000 person-years in the AI cohort and 0.93 in the non-AI cohort. After adjustment for age, sex, and comorbidities, the risks of DVT and PE were 3.40 95% confidence interval (CI) = 2.83-4.08 and 3.53 (95% CI = 2.69-4.65)-fold higher in the AI cohort than in the non-AI cohort.An increased incidence of VTE was observed among patients with AI. Therefore, physicians should carefully estimate the risk of VTE in patients with AI.
Shen et al. (Sun,) conducted a cohort in Alcohol intoxication and venous thromboembolism (n=306,145). Alcohol intoxication vs. Non-alcohol intoxication controls was evaluated on Deep vein thrombosis (DVT) incidence per 10,000 person-years (HR 3.40, 95% CI 2.83-4.08, p=<0.001). Alcohol intoxication was associated with a significantly increased risk of deep vein thrombosis (HR 3.40) and pulmonary embolism (HR 3.53) compared to non-intoxicated controls.