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YES ‐associated protein 1 ( YAP 1) plays a key role as a transcriptional coactivator in the Hippo tumor suppressor pathway. YAP 1 is overexpressed in a variety of cancers and is considered to be encoded by a proto‐oncogene. However, the role of YAP 1 remains debatable, because both gain and loss of YAP 1 expression have both been reported in breast cancer (BC). Here, we found that elevated expression of YAP 1 mRNA in BC was negatively correlated with relapse‐free, distant metastases‐free and overall survival rates. We then knocked down or overexpressed YAP 1 in human BC cells, and examined cell proliferation, apoptosis, and tumorigenic ability in vivo . We identified that YAP 1 promotes cell growth and inhibits cell apoptosis of BC through the phosphatase and tensin homolog deleted on chromosome 10– AKT signaling pathway, and thus suggest that YAP 1 might serve as a new target for inhibiting BC progression.
Guo et al. (Fri,) studied this question.