Lomitapide reduces low-density-lipoprotein cholesterol levels by approximately 40% in homozygous familial hypercholesterolemia patients on statin treatment.
Does lomitapide reduce LDL-C levels and is it tolerable in adult patients with homozygous familial hypercholesterolemia?
Lomitapide is an effective and tolerable treatment option that reduces LDL-C by approximately 40% in adult patients with homozygous familial hypercholesterolemia.
Lomitapide is an inhibitor of MTP, an enzyme located in the endoplasmic reticulum of hepatocytes and enterocytes. This enzyme is responsible for the synthesis of very low-density lipoproteins in the liver and chylomicrons in the intestine. Lomitapide has been approved by the US Food and Drug Administration, European Medicines Agency, and other regulatory agencies for the treatment of hypercholesterolemia in adult patients with homozygous familial hypercholesterolemia. Clinical trials have shown that lomitapide reduces low-density-lipoprotein cholesterol levels by around 40% in homozygous familial hypercholesterolemia patients on treatment with statins with or without low-density-lipoprotein apheresis, with an acceptable safety and tolerance profile. The most common adverse events are gastrointestinal symptoms that decrease in frequency with long-term treatment, and the increase in liver fat remains stable. This review analyzes the clinical use, efficacy, and tolerability of lomitapide.
Alonso et al. (Sun,) conducted a review in homozygous familial hypercholesterolemia. Lomitapide was evaluated on low-density-lipoprotein cholesterol levels. Lomitapide reduces low-density-lipoprotein cholesterol levels by approximately 40% in homozygous familial hypercholesterolemia patients on statin treatment.