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This work investigates the impact of dengue virus on male fertility, particularly focusing on sperm DNA integrity.

May 29, 2026Open Access

Mosquito-borne viruses and male infertility: Zika was just the beginning – the impact of dengue on sperm DNA integrity

Key Points

This work investigates the impact of dengue virus on male fertility, particularly focusing on sperm DNA integrity.
Reviewed existing literature on dengue virus and its effects on male reproductive health.
Compared findings with Zika virus-related fertility impacts.
Discussed implications for fertility counseling based on the evidence.
Dengue infection is linked to temporary declines in sperm count.
Sperm DNA fragmentation may increase due to fever and oxidative stress during acute dengue.
Insights from dengue are presented alongside Zika's known effects.

Abstract

Dengue is resurging globally (~14 million cases in 2024). Emerging evidence suggests that dengue infection may transiently impair male fertility. Acute dengue has been associated with reversible declines in sperm count, with potential increases in sperm DNA fragmentation, possibly mediated by fever-induced oxidative stress. We review dengue’s effects on sperm, compare them with Zika’s impact, and highlight implications for fertility counseling.

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Cite This Study

Tariq et al. (Wed,) studied this question.

synapsesocial.com/papers/6a192eb9fab5b468c4417f79 https://doi.org/https://doi.org/10.1097/ms9.0000000000005181

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