Mild or more advanced depression was associated with a 69% higher risk of incident cardiovascular disease compared to no depression in Chinese adults (HR 1.69).
Cohort (n=7,735)
Yes
Does depression increase the risk of incident cardiovascular diseases in Chinese adults?
Depression is independently associated with a significantly increased risk of incident cardiovascular disease and acute myocardial infarction in Chinese adults, particularly among women, individuals under 65, and non-smokers.
Effect estimate: HR 1.69 (95% CI 1.08, 2.64)
Absolute Event Rate: 6.55% vs 3.57%
p-value: p=<0.05
To examine possible associations between depression and cardiovascular disease (CVD) incidence and whether demographic factors modified those associations in the Chinese population. This prospective cohort study comprised 7,735 adults aged 18 years or older in Guizhou, China from 2010 to 2020. The Patient Health Questionnaire-9 (PHQ-9) was used to measure the prevalence of depression. Cox proportional hazard models were used to estimated hazard ratios (HRs) and 95% confidence intervals (95%CIs) of depression and incident CVD. We identified 215 CVD cases (including 28 acute myocardial infarction (AMI) and 197 stroke cases) during an average follow-up of 7.07 years. In the multivariable-adjusted model, baseline PHQ-9 score was associated with incident CVD, AMI, and stroke. The HR per 1-SD increase for PHQ-9 score was 1.14 (95%CI: 1.03, 1.26) for CVD, 1.26 (95%CI: 1.01, 1.57) for AMI, and 1.12 (95%CI: 1.01, 1.25) for stroke. Compared with participants without depression, those with any mild or more advanced depression had a higher risk of incident CVD (HR: 1.69, 95%CI: 1.08, 2.64) and AMI (HR: 3.36, 95%CI: 1.17, 10.56). Associations between depression with CVD and stroke were suggested to be even stronger among women and participants aged 65 years ( P for interaction 0.05). The effect of depression on stroke tended to be preserved in non-smokers. Depression was associated with a higher risk of incident CVD, AMI, and stroke in adults of Southwest, China, particularly in women, participants aged 65 years, and non-smokers. These findings highlighted the importance and urgency of depression healthcare.
Yu et al. (Wed,) conducted a cohort in Cardiovascular disease (n=7,735). Depression (PHQ-9 score ≥ 5) vs. No depression (PHQ-9 score = 0) was evaluated on Incident cardiovascular disease (CVD) (HR 1.69, 95% CI 1.08, 2.64, p=<0.05). Mild or more advanced depression was associated with a 69% higher risk of incident cardiovascular disease compared to no depression in Chinese adults (HR 1.69).