Left atrial volume and left atrial volume index at 12 months were significantly higher in patients with atrial fibrillation recurrence after cryoballoon-based pulmonary vein isolation.
Cohort (n=50)
Do baseline left atrial volume, left atrial volume index, galectin-3, and neutrophil-to-lymphocyte ratio predict atrial fibrillation recurrence following cryoballoon-based pulmonary vein isolation in patients with symptomatic paroxysmal atrial fibrillation?
Left atrial volume and left atrial volume index are useful predictors of left atrial remodeling and AF recurrence after cryoballoon-based PVI, whereas Gal-3 and N/L ratio are not.
Absolute Event Rate: 53.24% vs 42.08%
p-value: p=0.037
Cryoballoon-based pulmonary vein isolation (PVI) is a treatment option for atrial fibrillation (AF). Left atrial volume (LAV) and left atrial volume index (LAVi) are important parameters for long term success of PVI. Galectin-3 (Gal-3) and neutrophil to lymphocyte ratio (N/L ratio) are biomarkers to demonstrate the cardiac fibrosis and remodelling. 50 patients with symptomatic PAF despite ≥1 antiarrhythmic drug(s), who underwent PVI were enrolled. LAV, LAVi, Gal-3 and N/L ratio were calculated before ablation and after ablation at 6 and 12 months. According to AF recurrence patients were divided into two groups, recurrent AF (n = 14) and non-recurrent AF (n = 36). In both groups (recurrent and non-recurrent), initial and 12 months follow-up LAV values were 41.39 ± 18.13 ml and 53.24 ± 22.11 ml vs 48.85 ± 12.89 ml and 42.08 ± 13.85 (p = 0.037). LAVi were 20.9 ± 8.91 ml/m2 and 26.85 ± 11.28 ml/m2 vs 25.36 ± 6.21 and 21.87 ± 6.66 (p = 0.05) for recurrent and non-recurrent AF groups, respectively. In both groups PVI had no significant effect on serum Gal-3 levels and N/L ratio during 12 months follow-up. The comparison between two groups at the end of 12th month showed Gal-3 values of 6.66 ± 4.09 ng/ml and 6.02 ± 2.95 ng/ml (p = 0.516), N/L ratio values of 2.28 ± 1.07 103/μl and 1.98 ± 0.66 103/μl (p = 0.674). LAV and LAVi are useful to predict the remodelling of the left atrium and AF recurrence after cryoballoon-based PVI. However, biomarkers such as Gal-3 and N/L ratio are not associated with AF recurrence.
Çelik et al. (Tue,) conducted a cohort in Paroxysmal atrial fibrillation (n=50). Cryoballoon-based pulmonary vein isolation vs. Non-recurrent atrial fibrillation was evaluated on Left atrial volume (LAV) at 12 months (p=0.037). Left atrial volume and left atrial volume index at 12 months were significantly higher in patients with atrial fibrillation recurrence after cryoballoon-based pulmonary vein isolation.