Key points are not available for this paper at this time.
. Median Lp(a)-OxPL total concentration did not differ although particle concentration of four OxPL subspecies, in particular ALDOPC, decreased from AAD to the DASH-type diet (P = 0.001). Of 440 Lp(a) lipids annotated, 87 species (20%) responded significantly to SFA reduction, with major changes in phosphatidylcholine, sphingomyelin, and alkylphosphatidylcholine classes. A marked Lp(a)-lipidome difference between diets was observed for participants with higher (≥50 mg/dl) but not with lower (22 Kringles. In conclusion, dietary SFA reduction in African-Americans resulted in significant changes in the Lp(a)-lipidome with differences by Lp(a) levels and apo(a) sizes. The findings support a dynamic intraindividual nature of the Lp(a)-lipidome and an impact of metabolic regulation.
Myagmarsuren et al. (Thu,) studied this question.