Early natural menopause (40-45 years) was associated with an increased risk of heart failure compared with menopause at 50-54 years (HR 1.40; 95% CI 1.19 to 1.64).
Cohort (n=22,256)
Does early natural menopause increase the risk of incident heart failure in postmenopausal women?
Early natural menopause (age 40-45) is associated with a significantly increased risk of incident heart failure, an effect that is further exacerbated by smoking.
Effect estimate: HR 1.40 (95% CI 1.19 to 1.64)
OBJECTIVE: We investigated whether younger age at natural menopause confers a risk of heart failure. We also examined a possible modifying effect of tobacco smoking. METHODS: This study used the population-based Swedish Mammography Cohort; 22,256 postmenopausal women with information on age at natural menopause were followed from 1997 through 2011. First event of heart failure was ascertained through the Swedish National Patient Register and the Cause of Death Register. Cox proportional hazards regression analyses were conducted to estimate multivariable-adjusted hazard ratios (HRs) and 95% CIs. RESULTS: During a mean follow-up of 13 years, we ascertained 2,532 first events of heart failure hospitalizations and deaths. The mean age at menopause was 51 years. Early natural menopause (40-45 y), compared with menopause at ages 50 to 54 years, was significantly associated with heart failure (HR, 1.40; 95% CI, 1.19 to 1.64). In analyses stratified by smoking status, similar HRs were observed for this age group among never smokers (HR, 1.33; 95% CI, 1.06 to 1.66) and ever smokers (HR, 1.39; 95% CI, 1.09 to 1.78). Among ever smokers, increased incidence (HR, 1.25; 95% CI, 1.06 to 1.47) of heart failure could be detected even among those who entered menopause at ages 46 to 49 years. We found a significant interaction between age at natural menopause and smoking (P = 0.019). CONCLUSIONS: This study indicates that women who experience early natural menopause are at increased risk for developing heart failure and that smoking can modify the association by increasing the risk even among women who enter menopause around ages 46 to 49 years.
Rahman et al. (Tue,) conducted a cohort in Heart failure (n=22,256). Early natural menopause (40-45 years) vs. Menopause at ages 50 to 54 years was evaluated on First event of heart failure hospitalizations and deaths (HR 1.40, 95% CI 1.19 to 1.64). Early natural menopause (40-45 years) was associated with an increased risk of heart failure compared with menopause at 50-54 years (HR 1.40; 95% CI 1.19 to 1.64).