Diabetes and Associated Variables in the South Australian Aboriginal

Summary: Diabetes and associated variables in the South Australian Aboriginal. P. H. Wise, F. M. Edwards, R. J. Craig, B. Evans, J. B. Murchland, B. Sutherland and D. W. Thomas Diabetes of a predominant maturity‐onset type has been identified as being up to ten times more prevalent in South Australian Aborigines than in Caucasians. On the evidence provided, nutritional status and obesity are thought to be dominant in the aetiology of the hyperglycaemia, although relative hyperinsulinaemia in full blood Aborigines suggests a significant racial genetic effect. It is suggested on these and other grounds that the diabetic genotype may represent a factor of previous survival advantage to the Aboriginal, now rendered deleterious by urbanization. The degree of hyperglycaemia, and its association with hyperlipidaemia, obesity, retinal arteriovenous changes and abnormal electrocardiographic findings, accentuates the significance of the diabetes, and underlines the serious need for ongoing nutritional education in these communities.