Using the RDIa5 index based on heart rate acceleration reclassified 59% of type 1 and 55% of type 3 recording patients to higher OSA severity categories compared to AHI.
Observational (n=151)
Does the use of heart rate acceleration arousals (RDIa5) capture more respiratory disturbance events and alter OSA severity classification compared to standard AHI in patients with suspected OSA?
Incorporating heart rate acceleration as a surrogate for autonomic arousals detects more respiratory disturbance events and reclassifies a significant proportion of patients to higher OSA severity categories compared to standard AHI.
BACKGROUND: Autonomic arousals can be considered as surrogates of electroencephalography (EEG) arousals when calculating respiratory disturbance index (RDI). The main objective of this proof of concept study was to evaluate the use of heart rate acceleration (HRa) arousals associated with sleep respiratory events in a population undergoing full polysomnography (type 1) and in another undergoing portable monitor study (type 3). Our hypothesis is that when compared to other commonly used indexes, RDI based on HRa will capture more events in both types of recording. MATERIALS AND METHODS: A retrospective analysis was performed in two different populations of patients with suspected OSA: a) 72 patients undergoing one night of type 1 recording and b) 79 patients undergoing one night of type 3 recording. Variables for type 1 were 4% oxygen desaturation index (ODI), apnea/hypopnea index (AHI), RDI based on EEG arousals (RDIe), and RDI based on HRa with threshold of 5bpm (RDIa5). For type 3, variables were 4% ODI, AHI, and RDIa5 (it is not possible to calculate RDIe due to the absence of EEG). Calculated data were 1) Mean values for each sleep disturbance index in type 1 and 3 recordings; 2) Frequency of migration from lower to higher OSA severity categories using RDIa5 in comparison to AHI (thresholds: ≥5/h mild, ≥15/h moderate, ≥30/h severe); and 3) Bland-Altman plots to assess agreement between AHI vs RDIe and RDIa5 in type 1 population, and AHI vs RDIa5 in type 3 populations. RESULTS: More respiratory disturbance events were captured with RDIa5 index in both type 1 and type 3 recordings when compared to the other indexes. In type 1 recording, when using RDIa5 37% of patients classified as not having OSA with AHI were now identified as having OSA, and a total of 59% migrated to higher severity categories. In type 3 recording, similar results were obtained, as 37% of patients classified as not having OSA with AHI were now identified as having OSA using RDIa5, and a total of 55% patients migrated to higher severity categories. Mean differences for RDIa5 and AHI in type 1 and 3 populations were similar. CONCLUSION: The use of autonomic arousals such as HRa can help to detect more respiratory disturbance events when compared to other indexes, being a variable that may help to capture borderline mild cases. This becomes especially relevant in type 3 recordings. Future research is needed to determine its validity, optimization, and its clinical significance.
Mayer et al. (Wed,) conducted a observational in Suspected obstructive sleep apnea (OSA) (n=151). Respiratory disturbance index based on heart rate acceleration (RDIa5) vs. Apnea/hypopnea index (AHI) and RDI based on EEG arousals (RDIe) was evaluated on Frequency of migration from lower to higher OSA severity categories using RDIa5 in comparison to AHI. Using the RDIa5 index based on heart rate acceleration reclassified 59% of type 1 and 55% of type 3 recording patients to higher OSA severity categories compared to AHI.
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