High-intensity interval training for 8 weeks decreased caspase-3 and increased melusin and FAK gene expression in the cardiac tissue of methamphetamine-dependent rats compared to controls.
Does high-intensity interval training reduce cardiac apoptosis markers in methamphetamine-dependent rats?
High-intensity interval training may have a protective effect against methamphetamine-induced cardiac apoptosis in a rat model.
Chronic methamphetamine use increases apoptosis, leading to heart failure and sudden cardiac death. Previous studies have shown the importance of high-intensity interval training (HIIT) in reducing indices of cardiac tissue apoptosis in different patients, but in the field of sports science, the molecular mechanisms of apoptosis in methamphetamine-dependent rats are still unclear. The present article aimed to investigate the changes in cardiac apoptosis markers in methamphetamine-dependent rats in response to HIIT. Left ventricular tissue was used to evaluate caspase-3, melusin, FAK, and IQGAP1 gene expression. Rats were divided into four groups: sham, methamphetamine (METH), METH-control, and METH-HIIT. METH was injected for 21 days and then the METH-HIIT group performed HIIT for 8 weeks at 5 sessions per week. The METH groups showed increased caspase-3 gene expression and decreased melusin, FAK, and IQGAP1 when compared to the sham group. METH-HIIT showed decreased caspase-3 and increased melusin and FAK gene expression compared with the METH and METH-control groups. The IQGAP1 gene was higher in METH-HIIT when compared with METH, while no difference was observed between METH-HIIT and METH-control. Twenty-one days of METH exposure increased apoptosis markers in rat cardiac tissue; however, HIIT might have a protective effect, as shown by the apoptosis markers.
Shahrabadi et al. (Mon,) conducted a other in Methamphetamine dependence. High-Intensity Interval Training (HIIT) vs. Sham, METH, and METH-control groups was evaluated on Cardiac apoptosis markers (caspase-3, melusin, FAK, and IQGAP1 gene expression). High-intensity interval training for 8 weeks decreased caspase-3 and increased melusin and FAK gene expression in the cardiac tissue of methamphetamine-dependent rats compared to controls.