Speckle tracking echocardiography-based strain analysis detected subtle differences in pressure overload-induced myocardial remodelling between young and adult rats after 9 weeks of TAC.
Does speckle tracking echocardiography detect differences in pressure overload-induced myocardial remodeling between young and adult rats?
Speckle tracking echocardiography can detect subtle differences in pressure overload-induced myocardial remodeling between young and adult rats.
The assessment by speckle tracking echocardiography (STE) provides useful information on regional and global left ventricular (LV) functions. The aim of the study is to investigate if STE-based strain analysis could detect the difference of pressure overload-induced myocardial remodelling between young and adult rats. Physiological, haemodynamic, histological measurements were performed post-operatively in young and adult rats with transverse aortic constriction (TAC) as well as the age-matched shams. Two-way ANOVA was used to detect the statistical difference of various measured parameters. Pressure overload decreased the ejection fraction, fractional shortening, d p /d t max and | d p / d t min | , but increased the LV end-diastolic (ED) pressure in adult rat hearts for nine weeks after TAC operation than those in young rat hearts. Pressure overload also resulted in different changes of peak strain and strain rate in the free wall, but similar changes in the interventricular septum of young and adult rat hearts. The changes in myocardial remodelling were confirmed by the histological analysis including the increased apoptosis rate of myocytes and collagen area ratio in the free wall of adult rat hearts of LV hypertrophy when compared with the young. Pressure overload alters myocardial components in different degrees between young and adult animals. STE-based strain analysis could detect the subtle difference of pressure overload-induced myocardial remodelling between young and adult rats.
Niu et al. (Sat,) conducted a other in Pressure overload-induced myocardial remodelling. Transverse aortic constriction (TAC) and speckle tracking echocardiography vs. Age-matched shams was evaluated on Difference in pressure overload-induced myocardial remodelling (peak strain and strain rate). Speckle tracking echocardiography-based strain analysis detected subtle differences in pressure overload-induced myocardial remodelling between young and adult rats after 9 weeks of TAC.