Analysis of the relationship between the level of high-sensitive C-reactive protein and the risk factors of cardiovascular diseases in young and middle-aged persons

Objective. To evaluate the relationship between the level of high-sensitive C-reactive protein young and middle-aged people without history of cardiovascular complications. Methods. Data from 427 patients aged 30-55 years old (median age -41 years old; men -83%), based on the center of diagnosis and rehabilitation of «Gazprom Transgaz Moscow» LLC from November 2018 to February 2020 were analyzed. All the participants conducted a comprehensive examination in accordance with the employee profession and order No. 302 of the Ministry of Health of the Russian Federation. Blood hs-CRP level was determined by an immunoturbodimetric method with latex amplification, with a lower detection limit of 0.1 mg/l. Results. Hs-CRP in comparison with a normal body weight participants (0.52 0.32;0.98 mg/l) was significantly higher in overweight persons (1.23 0.68;2.11 mg/l) and in obese patients (1.84 1.27;3.11 mg/l), as well as in patients with obesity in comparison with patients with overweight (p=0.0001 in all cases). The hs-CRP level in a group with systolic blood pressure (SBP) 120-129 mm Hg hs-CRP was 0.96 0.50;1.96 mg/l, in the group with SBP 130-139 mm Hg - 1.52 0.83;2.77 mg/l, in patients with SBP >140 mm Hg- 1.54 1.03;2.19 mg/l (p = 0.0002). Similar significant (p=0.0002) relationships are revealed for office diastolic blood pressure (DBP). In patients with a total blood cholesterol >4.9 mmol/l (n=355), the average level of hs-CRP was 1.24 0.60;2.19 mg/l, and in participant with normal total cholesterol (n=72) - 0.69 mg/l 0.37;1.80 (p = 0.002). Among all the analyzed persons, elevated levels of hs-CRP (> 2 mg/l) were associated with frequent flu (odds ratio (OR) 2.1, 95% confidence interval (CI) 1.2-3.7; p=0.02) and an increase in the erythrocytes sedimentation rate (ESR) (OR 3.5, 95 % CI 1.5-8.03; p=0.004). After adjustment for sex, age and confounders hs-CRP >2 mg/l significantly associated with abdominal obesity (OR 2.2, 95 % CI 1.2-4.2; p=0.01) and hypertension (OR 1.9, 95 % CI 1.1-3.3; p=0.02). Conclusion. In young and middle-aged persons passing PME, hs-CRP is a stable cardiovascular risk marker, associated with overweight, obesity, an increase in the total cholesterol level, office SBP and DBP, ESR, and with history of frequent flu.