High serum lactate dehydrogenase levels were associated with significantly worse overall survival (HR 2.90) and 5-year disease-free survival (HR 2.40) in patients with Ewing's sarcoma.
Meta-Analysis (n=1,412)
Do high serum lactate dehydrogenase (LDH) levels predict worse overall survival and 5-year disease-free survival in patients with Ewing's sarcoma?
High serum LDH levels are an effective biomarker associated with significantly lower overall and 5-year disease-free survival in patients with Ewing's sarcoma.
Effect estimate: HR 2.90 (95% CI 2.09-4.04)
p-value: p=<0.001
A number of studies have investigated the role of serum lactate dehydrogenase (LDH) levels in patients with Ewing's sarcoma, although these have yielded inconsistent and inconclusive results. Therefore, the present study aimed to systematically review the published studies and conduct a meta-analysis to assess its prognostic value more precisely. Cohort studies assessing the prognostic role of LDH levels in patients with Ewing's sarcoma were included. A pooled hazard ratio (HR) with 95% confidence intervals (CIs) of overall survival (OS) or 5-year disease-free survival (DFS) was used to assess the prognostic role of the levels of serum LDH. Nine studies published between 1980 and 2014, with a total of 1,412 patients with Ewing's sarcoma, were included. Six studies, with a total of 644 patients, used OS as the primary endpoint and four studies, with 795 patients, used 5-year DFS. Overall, the pooled HR evaluating high LDH levels was 2.90 (95% CI: 2.09-4.04) for OS and 2.40 (95% CI: 1.93-2.98) for 5-year DFS. This meta-analysis demonstrates that high levels of serum LDH are associated with lower OS and 5-year DFS rates in patients with Ewing's sarcoma. Therefore, serum LDH levels are an effective biomarker of Ewing's sarcoma prognosis.
Li et al. (Thu,) conducted a meta-analysis in Ewing's sarcoma (n=1,412). High serum lactate dehydrogenase (LDH) levels vs. Low/normal serum LDH levels was evaluated on Overall survival (HR 2.90, 95% CI 2.09-4.04, p=<0.001). High serum lactate dehydrogenase levels were associated with significantly worse overall survival (HR 2.90) and 5-year disease-free survival (HR 2.40) in patients with Ewing's sarcoma.