Do high levels of myocardial stress and inflammation biomarkers predict major cardiovascular adverse events in MI survivors?
A multimarker risk stratification approach using inflammation and myocardial stress biomarkers significantly improves the prediction of major cardiovascular adverse events in patients following a myocardial infarction.
Aim: Although there are short- and long-term prognostic studies in patients with myocardial infarction (MI), the data that can be used to predict the clinical outcome following discharge is limited. Materials & methods: We analyzed creatinine kinase-MB and troponin related to myonecrosis, suppression of tumorigenicity 2 and NT-pro B-type natriuretic peptide related to myocardial stress, C-reactive protein and procalcitonin related to inflammation in 259 MI patients. Results: Being in the high group for myocardial stress (odds ratio OR: 3.45, 95% CI: 1.398–8.547, p = 0.004) and inflammation markers (OR: 4.30, 95% CI: 1.690–10.899, p = 0.001) predicted major cardiovascular adverse events while myonecrosis markers could not (OR: 1.70, 95% CI: 0.671–4.306, p = 0.263). Conclusion: Using multimarker risk stratification composed of inflammation and myocardial stress biomarkers improves the prediction of major cardiovascular adverse events in MI survivors.
Somuncu et al. (Fri,) studied this question.