Excipients are of great importance in preparation of pharmaceuticals. They're inert, raw materials that are included in pharmaceutical preparation along with APIs, during development, to maintain stability in vivo as well as in vitro. They affect the quality of the pharmaceutical preparation. These assist in providing favourable pharmacokinetics and pharmacodynamics for the medication. Moreover, excipients are responsible for physical properties such as solubility, consistency, weight and volume, and the rate of release of the medication, making sure that the correct dosage of the drug is delivered through the prescribed dosage form. Recently a number of synthetic excipients are studied in many pharmaceutical compositions including tablets, capsules, and new drug delivery systems. But most of the synthetic excipients are having some side effects for administration. Hence the more interest is towards natural excipients that leads to less side effects and toxicity. Many natural excipients are available such as binders’ diluents sweetening agents, colorants, preservatives, film formers, which are found in large quantities in plants, animals and in the minerals. The non-toxic biocompatible biodegradable and affordable properties of the natural excipients have increased the interest of pharmaceutical companies to use the natural excipients in formulations with new drugs as well as in cosmetics and foods.
Kothawade et al. (Fri,) studied this question.