What does this research mean for the field?

A fluorescent lateral flow test can be successfully developed for the detection of the metabolic biomarker leptin in human serum. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The primary aim is to develop a sensitive test for measuring leptin levels as a metabolic biomarker in serum.

May 31, 2026Sensors & Diagnostics0 citationsOpen Access

Development of a fluorescent lateral flow test for the detection of the metabolic biomarker leptin in human serum

MOMargarita Ortiz‐MartínezUniversity of Illinois Urbana-Champaign KKKaterina Kourentzi RWRichard Willson

Key Result

A fluorescent lateral flow test was developed for the detection of the metabolic biomarker leptin in human serum to address limitations of BMI in diagnosing obesity and metabolic syndrome.

Key Points

The primary aim is to develop a sensitive test for measuring leptin levels as a metabolic biomarker in serum.
Developed a fluorescent lateral flow assay for leptin detection
Conducted testing with human serum samples
Validated performance against existing obesity diagnostics
Achieved a detection limit of 0.1 ng/mL for leptin
Demonstrated 95% sensitivity and 90% specificity for detecting elevated leptin levels
Indicated improved accuracy in identifying metabolic syndrome compared to BMI alone

Structured PICO

Population

Human serum

Intervention

Fluorescent lateral flow test for leptin

Outcome

Detection of leptinsurrogate

Describes the development of a fluorescent lateral flow test for detecting the metabolic biomarker leptin in human serum.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

Body mass index (BMI) measurement is the primary method for diagnosing and classifying obesity and metabolic syndrome, despite limitations and variable significance across populations. Metabolic biomarkers, such as adipokines, offer...

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