Does nitrate improve activity tolerance in patients with heart failure with preserved ejection fraction?
The provided text highlights the critical need for therapies to alleviate symptoms and improve quality of life in patients with HFpEF, introducing a trial evaluating nitrate's effect on activity tolerance.
The prevalence of heart failure (HF) with preserved ejection fraction (HFpEF) is increasing. Physicians caring for these patients currently have limited therapeutic options beyond diuresis and management of comorbid conditions. Hence there remains an immediate and critical need for therapies to alleviate symptoms and meaningfully improve quality of life for patients with HFpEF.
Zakeri et al. (Thu,) studied this question.