Sacubitril valsartan treatment in 49 HFrEF outpatients significantly improved LV volumes, mass, systo-diastolic function, and NYHA class at 12 months, though women showed less reverse remodelling.
Cohort (n=49)
Does sacubitril valsartan improve clinical and echocardiographic parameters in outpatients with HFrEF?
Sacubitril valsartan induces significant reverse cardiac remodeling and improves clinical status in HFrEF outpatients, though women may show a lesser extent of reverse remodeling compared to men.
AIM: Sacubitril valsartan (SV) has revolutionized disease history in patients with heart failure and reduced ejection fraction (HFrEF). Our study assessed SV impact on clinical and echocardiographic parameters in HFrEF outpatients previously treated with optimized therapy. METHODS: Forty-nine HFrEF outpatients were retrospectively included in the study. We collected data from transthoracic echocardiography and clinical assessment at baseline and after 3 ± 1 and 12 ± 1 months of treatment with SV. Results were also stratified by sex to analyse possible sex-based differences in reverse remodelling response to SV. RESULTS: After 3 months of treatment we observed a significative improvement of both systolic and diastolic function with a reduction of left ventricular mass and relative wall thickness (RWT). At 12 months we observed a further improvement of all previous parameters, plus systolic pulmonary artery pressure (PAP) and left atrial (LA) diameter. In women, most of the echocardiographic parameters improved after SV initiation, but did not reach the statistical significance, except for left ventricular ejection fraction (LVEF), PAP and LA diameter. As for clinical parameters, SV improved New York Heart Association (NYHA) Class, systolic blood pressure and loop diuretic dosage with a mild but significative increase in serum creatinine and potassium. CONCLUSION: Our study showed significative reverse remodelling properties of SV with an improvement of LV volumes, mass and systo-diastolic function. NYHA Class, systolic blood pressure and loop diuretic dosage also improved with only mild increase in serum creatinine and potassium. Women showed a lesser extent of reverse remodelling compared with men.
Landolfo et al. (Fri,) conducted a cohort in Heart failure and reduced ejection fraction (HFrEF) (n=49). Sacubitril valsartan vs. Baseline was evaluated on Clinical and echocardiographic parameters (including LV volumes, mass, systo-diastolic function, and NYHA class). Sacubitril valsartan treatment in 49 HFrEF outpatients significantly improved LV volumes, mass, systo-diastolic function, and NYHA class at 12 months, though women showed less reverse remodelling.
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