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Aeromonas hydrophila is a pathogen that causes disease in a wide range of homeothermic and poikilothermic hosts due to its multifactorial virulence. The production of many of these virulence determinants is associated with high cell density, a phenomenon that might be regulated by quorum sensing. The quorum sensing system regulates the expression of several virulence factors in a wide variety of pathogenic bacteria. To investigate the pathogenic role of quorum sensing system in A. hydrophila, We constructed an ahyI mutant strain of a fish-clinical isolate YJ-1, named YJ-1∆AhyI. Compared with the wild-type strain, the ahyI mutant strain exhibited a significant decrease of total extracellular virulent activity, and decreased in biofilm formation, intraperitoneal LD50 of YJ-1∆AhyI were more than 10 9 CFU, about 10 4 times higher than the parent strain. These results suggest that A.
Weihua Chu (Fri,) studied this question.