Charge Movement and the Nature of Signal Transduction in Skeletal Muscle Excitation-Contraction Coupling

The mechanism of transmission remains unclear. It is possible that release is reinforced by Ca(2+)-induced activation secondary to opening of release channels by another primary mechanism. Multiple results favor some function of IP3 in EC coupling; however, there are many arguments indicating that IP3 is not the primary transmitter. DHP receptors and ryanodine receptors are known to play essential roles in the triadic junction, but the biochemical make up of the junction has not been completely established, and there may be other essential proteins. The strongest argument in favor of mechanical coupling between voltage sensor and release channel is the close proximity of the channel protein to the T membrane and the fixed stoichiometry between sensors and channels.