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Cardiovascular disease (CVD) is the leading cause of mortality worldwide.CVD is primarily driven by modifiable risk factors, including physical inactivity, smoking, high fat and high salt diets resulting in hypertension and obesity.Amongst these modifiable risk factors, obesity has taken a central role in CVD development.Adipose tissue acts not only as a reservoir of fat, but as an endocrine organ, releasing a number of biologically active "adipokines" that can regulate metabolic homeostasis.Given the intricate relationship between obesity and CVD, is imperative to understand the signals by which adipose tissue influences cardiovascular physiology and disease.Indeed, many adipose tissue-derived molecules have the potential to act as biomarkers for diagnosis, prognosis and even therapeutic targets in CVD.In this review, we discuss the impact of adipose-derived molecules in the pathogenesis of several CVD etiologies, including ischemic heart disease and heart failure.
Maya-Ramos et al. (Sun,) studied this question.