In a canine model of acute coronary occlusion, collateral blood flow measured by Krypton-85 washout was inversely related to the mass of the ischemic myocardium.
Abstract Blood flow in the ischemic region during acute coronary occlusion in anesthetized open chest dogs was studied by external recording of wash out curves after intracoronary administration of Kr 85 . Flow values were satisfactorily well reproducible in 29 double determinations. Collateral blood flow ranged from 6 to 44 ml/min × 100 g tissue. The magnitude of flow was inversely related to the weight of the ischemic region in 14 of 20 dogs. In 6 dogs with the lowest flow values this correlation was only slightly indicated. Arterial occlusion did not seem to affect flow in adjacent nonischemic myocardium. The potential advantages of the present technique for the study of collateral blood flow are discussed in comparison with other methods.
Johansson et al. (Thu,) studied this question.
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